FEF25–75% trajectories from age 7 to 53 years, associations with childhood and parental preconception factors, and midlife COPD risk: a prospective cohort study

Existing trajectory studies have emphasised large-airway indices, but chronic obstructive pulmonary disease (COPD) might originate in smaller airways. This study aimed to investigate mid-to-small-airway function trajectories, their associated factors, and COPD risk.

Citation:
Liu J, Lodge CJ, Perret JL, Vicendese D, …….. Martino D, Mishra GD, et al. FEF25–75% trajectories from age 7 to 53 years, associations with childhood and parental preconception factors, and midlife COPD risk: a prospective cohort study. Lancet Respir Med. 2026.

Keywords:
COPD; chronic obstructive pulmonary disease; airway function; respiratory health survey;lung function; asthma; wheeze

Abstract:
Existing trajectory studies have emphasised large-airway indices, but chronic obstructive pulmonary disease (COPD) might originate in smaller airways. This study aimed to investigate mid-to-small-airway function trajectories, their associated factors, and COPD risk.