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Research
Changes in airway inflammation with pseudomonas eradication in early cystic fibrosisNeutrophil elastase is a significant risk factor for structural lung disease in cystic fibrosis, and Pseudomonas aeruginosa airway infection is linked with neutrophilic inflammation and substantial respiratory morbidity. We aimed to evaluate how neutrophil elastase (NE) activity changes after P. aeruginosa eradication and influences early disease outcomes. We assessed participants in the AREST CF cohort between 2000 and 2018 who had P. aeruginosa cultured from their routine annual bronchoalveolar lavage (BAL) fluid and who underwent eradication treatment and a post eradication BAL. Factors associated with persistent P. aeruginosa infection, persistent neutrophilic inflammation following eradication and worse structural lung disease one year post-eradication were evaluated.
Research
Do sex hormones at birth predict later-life economic preferences? Evidence from a pregnancy birth cohort study: Hormones at birth and preferencesEconomic preferences may be shaped by exposure to sex hormones around birth. Prior studies of economic preferences and numerous other phenotypic characteristics use digit ratios (2D : 4D), a purported proxy for prenatal testosterone exposure, whose validity has recently been questioned. We use direct measures of neonatal sex hormones (testosterone and oestrogen), measured from umbilical cord blood (n = 200) to investigate their association with later-life economic preferences (risk preferences, competitiveness, time preferences and social preferences) in an Australian cohort (Raine Study Gen2).
Research
Children's neighbourhood physical environment and early development: an individual child level linked data studyThe neighbourhood physical environment has a weak but significant association with early childhood development
Research
Healthy population ageing depends on investment in early childhood learning and developmentInterventions in the early years provide a sustainable solution by generating long-term labour productivity and social welfare benefits
News & Events
A world first for Aussie kids putting Australia's children on the mapIn a world first, 96 per cent of communities in Australia now have vital information about their children's development
News & Events
How mums talk influences children’s perspective-taking abilityNew research shows that kids whose mums talk more frequently about others' thoughts tend to be better at taking another's perspective than other children.
News & Events
WA researchers awarded $9.7 million for ground-breaking child health studiesWA researchers awarded $9.7 million for ground-breaking child health studies
News & Events
New approach needed to tackle child abuse and neglectLeading child advocates have called for a new approach to tackling child abuse and neglect amid rising rates of abuse notifications
Research
Alcohol-Related Harm in Young People (Oct 2015+)This project aims to inform harm prevention and minimisation strategies by investigating outcomes and points for early intervention in young people with alcohol-related harm. Researchers will also compare outcomes between Aboriginal and non-Aboriginal youth.
Research
Social support helps protects against depressed mood in adolescenceThe goals of the current study were to identify different trajectories of sadness from Grade 6 to 9 in Australian school students, and to explore the role that social support from school, teachers, friends and families play in supporting students’ mental health.