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Severe hypoglycemia rates are not associated with HbA1c: A cross-sectional analysis of 3 contemporary pediatric diabetes registry databasesTo examine the association between glycated hemoglobin (HbA1c) and severe hypoglycemia rates in patients with type 1 diabetes receiving usual care.
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A randomized comparison of three prandial insulin dosing algorithms for children and adolescents with Type 1 diabetesThe Pankowska Equation resulted in reduced postprandial hyperglycaemia at the expense of an increase in hypoglycaemia
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Machine learning and clinical epigenetics: a review of challenges for diagnosis and classificationWe now have a growing number of epigenetic alterations in disease, and this offers a chance to increase sensitivity and specificity of future diagnostics and therapies
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Differential SLC6A4 methylation: a predictive epigenetic marker of adiposity from birth to adulthoodThese data suggest that altered methylation of CpG loci within SLC6A4 may provide a robust marker of adiposity across the life course
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Copeptin Kinetics and Its Relationship to Osmolality During Rehydration for Diabetic Ketoacidosis in ChildrenCopeptin is a surrogate marker for arginine vasopressin (AVP) release in response to hyperosmolal stimuli such as diabetic ketoacidosis (DKA). The objective of this work is to characterize kinetics of copeptin and osmolality, and their dynamic relationship during rehydration and insulin therapy in children with type 1 diabetes (T1D) and DKA.
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DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studiesDNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models.
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Modelling the effects of beverage substitution during adolescence on later obesity outcomes in early adulthood: Results from the raine studySugar-sweetened beverage intake during adolescence was associated with higher body mass index, waist circumference, and being overweight in early adulthood
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First genome-wide association study in an Australian Aboriginal population provides insights into genetic risk factors for body mass index and type 2 diabetesA body mass index (BMI) >22kg/m2 is a risk factor for type 2 diabetes (T2D) in Aboriginal Australians.
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Effect of exercise intensity on glucose requirements to maintain euglycemia during exercise in type 1 diabetesInverted-U relationship between exercise intensity and glucose requirement
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Increasing incidence of type 2 diabetes in Indigenous and non-Indigenous children in Western Australia, 1990-2012In this study, we aimed to determine the incidence and incidence rate trends of childhood T2D in Indigenous and non-Indigenous children in WA.