Search
Showing results for "early life"
News & Events
New team members!CliniKids recently welcomed Gayle, Tarryn and Emma to the clinical team. The clinicians will be located out our new Joondalup clinic, which will be welcoming families in Term 4.
Research
Multiomics and Systems Biology Are Needed to Unravel the Complex Origins of Chronic DiseaseIn this concept paper, we discuss multiomic approaches to studying immune dysregulation and highlight some of the challenges and opportunities
News & Events
WANdiab patient management system upgradeWe've updated our clinical diabetes patient management system to a new state-of-the art system that can access critical informtion in real-time during clinic.
Research
Study Protocol for a Randomised Controlled Trial Investigating the Effects of Maternal Prebiotic Fibre Dietary Supplementation from Mid-Pregnancy to Six Months’ Post-Partum on Child Allergic Disease OutcomesInfant allergy is the most common early manifestation of an increasing propensity for inflammation and immune dysregulation in modern environments. Refined low-fibre diets are a major risk for inflammatory diseases through adverse effects on the composition and function of gut microbiota. This has focused attention on the potential of prebiotic dietary fibres to favourably change gut microbiota, for local and systemic anti-inflammatory effects.
Research
Transplacental immune modulation with a bacterial-derived agent protects against allergic airway inflammationThese data provide proof of concept supporting the rationale for developing transplacental immune reprogramming approaches for primary disease prevention
Research
The PrEggNut Study – Maternal diet rich in eggs and peanuts to reduce food allergies: a randomised controlled trialDebbie Susan Palmer Prescott BSc BND PhD MBBS BMedSci PhD FRACP Head, Nutrition in Early Life Honorary Research Fellow debbie.palmer@uwa.edu.au
Research
PKC activation promotes maturation of cord blood T cells towards a Th1 IFN-γ propensityA significant number of babies present transiently with low protein kinase C zeta (PKCζ) levels in cord blood T cells, associated with reduced ability to transition from a neonatal Th2 to a mature Th1 cytokine bias, leading to a higher risk of developing allergic sensitisation, compared to neonates whose T cells have 'normal' PKCζ levels. However, the importance of PKCζ signalling in regulating their differentiation from a Th2 to a Th1 cytokine phenotype propensity remains undefined.
Research
Beyond Plants: The Ultra-Processing of Global Diets Is Harming the Health of People, Places, and PlanetGlobal food systems are a central issue for personal and planetary health in the Anthropocene. One aspect of major concern is the dramatic global spread of ultra-processed convenience foods in the last 75 years, which is linked with the rising human burden of disease and growing sustainability and environmental health challenges.
Research
Characterization of the transient deficiency of pkc isozyme levels in immature cord blood t cells and its connection to anti‐allergic cytokine profiles of the matured cellsCord blood T cells (CBTC) from a proportion of newborns express low/deficient levels of some protein kinase C (PKC) isozymes, with low levels of PKCζ correlating with increased risk of developing allergy and associated decrease in interferon‐gamma (IFN‐γ) producing T cells.
Research
Earth dreams: Reimagining ARPA for health of people, places and planetBold new approaches are urgently needed to overcome global health challenges. The proposed Advanced Research Projects Agency for Health (ARPA-H) is intended to provide rapid health breakthroughs.