Skip to content

Search

Showing results for "early life"

Suppression of TGF-β/SMAD signaling by an inner nuclear membrane phosphatase complex

Cytokines of the TGF-β superfamily control essential cell fate decisions via receptor regulated SMAD (R-SMAD) transcription factors. Ligand-induced R-SMAD phosphorylation in the cytosol triggers their activation and nuclear accumulation. We determine how R-SMADs are inactivated by dephosphorylation in the cell nucleus to counteract signaling by TGF-β superfamily ligands. 

Optimisation of the sampling method for skin microbiome studies in healthy children: a pilot cohort study

Recent interest in the diverse ecosystem of bacteria, fungi and viruses that make up the skin microbiome has led to numerous studies investigating the skin microbiome in healthy skin and in dermatological conditions. However, skin microbiome analysis is challenging due to relatively low numbers of skin microorganisms compared to mucosal sites, such as the respiratory or gastrointestinal tracts. Microbiome results are heavily influenced by sampling methods.

Characterising Insistence on Sameness and Circumscribed Interests: A Qualitative Study of Parent Perspectives

Manifestations of insistence on sameness and circumscribed interests are complex, with individuals varying considerably, not only in the types of behaviours they express, but also in terms of a behaviour's frequency, intensity, trajectory, adaptive benefits, and impacts.

Utilising Behavioural and Sensory Profiles and Associated Perinatal Factors to Identify Meaningful Subgroups in Autism Spectrum Disorder

The heterogeneity of autism spectrum disorder clinically and aetiologically hinders intervention matching and prediction of outcomes. This study investigated if the behavioural, sensory, and perinatal factor profiles of autistic children could be used to identify distinct subgroups. Participants on the autism spectrum aged 2 to 17 years and their families were sourced via the Australian Autism Biobank.

Fellowship drives research

Meet Keely Bebbington. The clinical psychologist recently joined the Children’s Diabetes Centre as the McCusker Research Fellow in Type 1 Diabetes — a Fellowship that was established in response to the need for a dedicated focus on the mental health and wellbeing of young people with Type 1 Diabetes

Tips for a good clinic visit

The Diabetes Service at Perth Children’s Hospital cares for approximately 1000 children with diabetes. Read these tips to ensure you have a good visit.

Healthy holiday habits

The school holidays and Christmas are a welcome break for most families but the lack of routine can prove a trying time for families living with Type 1 Diabetes

Paediatric Autism Communication Therapy

At CliniKids, we offer a communication therapy called PACT to caregivers of children who would like some additional support to understand their child’s communication.

Building resilience with type one diabetes

Increasing resilience is critical to reduce the burden of living with type one diabetes (T1D), according to participants of a new study.

Senior researcher presents at perinatal mental health conference

Senior Embrace researcher Dr Alix Woolard has called for more support for NICU parents and families at the 2025 Perinatal and Infant Mental Health Symposium.