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Research

Reduction in hypoglycemia with the predictive low-Glucose management system: A long-term randomized controlled trial in adolescents with type 1 diabetes

Short-term studies with automated systems that suspend insulin when hypoglycemia is predicted have shown a reduction, but safety and efficacy aren't established

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Pre-onset risk characteristics for mania among young people at clinical high risk for psychosis

We aimed to identify the rate and predictors of transition to mania in a cohort of youth with clinical or familial risk for psychosis.

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Initial acquisition and succession of the cystic fibrosis lung microbiome is associated with disease progression in infants and preschool children

We characterized the lower airways microbiome using BAL samples obtained from clinically stable CF young children who underwent bronchoscopy and chest CT.

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Diffuse Intrinsic Pontine Glioma

This chapter summarizes recent advances in diffuse intrinsic pontine glioma and potential novel therapies

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Insulin Pump Therapy in Adolescents With Very Poor Glycemic Control During a 12-Month Cohort Trial

We conclude that insulin pump therapy can be an effective tool to improve glycemic control in adolescents with long-standing treatment resistance

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Conserved temporal ordering of promoter activation implicates common mechanisms governing the immediate early response across cell types and stimuli

We obtain a set of 57 candidate immediate early genes possessing promoters that consistently drive a rapid but transient increase in expression over time

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Associations between proposed local government liquor store size classifications and alcohol consumption in young adults

Young adults' alcohol consumption appears to be impacted by liquor store density and convenience, rather than outlet size

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Performance of medtronic hybrid closed-loop iterations: Results from a randomized trial in adolescents with type 1 diabetes

This study investigates the performance of an iteration of the Medtronic hybrid closed-loop algorithm

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Impact of the Friendly Schools whole-school intervention on transition to secondary school and adolescent bullying behaviour

These findings demonstrate the immediate value of whole-school interventions to reduce bullying behaviour and associated harms among students