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Research

Validation of a mouse xenograft model system for gene expression analysis of human acute lymphoblastic leukaemia

Pre-clinical models that effectively recapitulate human disease are critical for expanding our knowledge of cancer biology and drug resistance mechanisms.

Research

The Second Research Report: patterns and trends in mortality of Western Australian infants, children and young people 2004-2005

This report was commissioned by the Department for Child Protection as an ongoing initiative to continue the work initiated by researchers at the Telethon Kids

Research

Interpretation of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine is adversely affected by methodological inaccuracies when using a commercial ELISA

The DNA lesion 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), a urinary marker of oxidative stress, is produced from reactions of reactive oxygen

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The transient value of classifying preschool wheeze into episodic viral wheeze and multiple trigger wheeze

A recently proposed method for classifying preschool wheeze is to describe it as either episodic (viral) wheeze or multiple trigger wheeze.

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In utero exposure to antidepressant medication and neonatal growth outcomes: closer examination of the evidence is needed

In utero exposure to antidepressant medication and neonatal growth outcomes: closer examination of the evidence is needed

Research

Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm

We assessed the association between ApoE genotype with AAA presence and growth, and serum C-reactive protein (CRP).

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Assessing the protective effect of influenza vaccine against laboratory confirmed influenza in hospitalised children aged 6-59 months

Influenza vaccine was offered to all children aged 6-59 months resident in Western Australia in 2008, and we wished to evaluate the effectiveness of this immunisation programme.

Research

CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study

To look at the interplay between PMN and macrophages in disease progression in humans we asked whether polymorphisms at genes that regulate their infiltration..

Research

Interpretation of recent sudden infant death syndrome rates in Western Australia

Data for recent years show a shift away from a classification of 'SIDS' towards a classification of 'unascertainable', particularly for Aboriginal infants.

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Predictors of seizure onset in Rett syndrome

Information on presence and age at onset of seizures, perinatal and developmental history, and genetic status was abstracted on 275 cases in the Australian...